"DICA heeft een meer gestandaardiseerde manier om grote aantallen observationele data te verzamelen"
De kans op verantwoord onderzoek, Oncologieuptodate vol 9, nr3Bekijk artikel
Publicatie met data uit de Dutch ColoRectal Audit (DCRA) in het European Journal of Surgical Oncology:
Obesity as a determinant of perioperative and postoperative outcome in patients following colorectal cancer surgery: A population-based study (2009-2016).
Auteurs: Y.Q.M. Poelemeijer, N. Lijftogt, R. Detering, M. Fiocco, R.A.E.M. Tollenaar & M.W.J.M. Wouters.
Bekijk hier het hele artikel of lees hieronder de samenvatting:
Background: Obesity is an increasing problem worldwide that can influence perioperative and post- operative outcomes. However, the relationship between obesity and treatment-related perioperative and short-term postoperative morbidity after colorectal resections is still subject to debate.
Study: Patients were selected from the DCRA, a population-based audit including 83 hospitals per- forming colorectal cancer (CRC) surgery. Data regarding primary resections between 2009 and 2016 were eligible for analyses. Patients were subdivided into six categories: underweight, normal weight, over- weight and obesity class I, II and III.
Results: Of 71,084 patients, 17.7% with colon and 16.4% with rectal cancer were categorized as obese. Significant differences were found for the 30-day overall postoperative complication rate (p < 0.001), prolonged hospitalization (p < 0.001) and readmission rate (colon cancer p < 0.005; rectal cancer p < 0.002) in obese CRC patients. Multivariate analysis identified BMI !30 kg/m2 as independent pre- dictor of a complicated postoperative course in CRC patients. Furthermore, obesity-related comorbidities were associated with higher postoperative morbidity, prolonged hospitalization and a higher read- mission rate. No significant differences in performance were observed in postoperative outcomes of morbidly obese CRC patients between hospitals performing bariatric surgery and hospitals that did not.
Conclusion: The real-life data analysed in this study reflect daily practice in the Netherlands and identify obesity as a significant risk factor in CRC patients. Obesity-related comorbidities were associated with higher postoperative morbidity, prolonged hospitalization and a higher readmission rate in obese CRC patients. No differences were observed between hospitals performing bariatric surgery and hospitals that did not.